Project One: Cell specific PACAP-CRF effects in Mice

The goal of Project 1 is to dissect the molecular events within specific neuron populations that underlie the stress response.

Project 1 is designed to operate at a deep mechanistic level to understand the role of cell-type specific CRF- and PACAP-expressing neuron populations within central amygdala (CeA), bed nucleus of the stria terminalis (BNST), prefrontal cortex (PFC), and parabrachial nucleus (PBn). Our hypothesis is that differential regulation of miRNA, mRNA, and DNA methylation, in CRF and PACAP neurons of the CeA, BNST, PFC, and PBn will identify new targets for stress-related disorders.


Kerry Ressler, MD, PhD

Co-Director of SPARED Conte Center and Priniciple Investigator of Project One

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Nikolaos Daskalakis, PhD

Co-Investigator of Project One

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Christos Chatzinakos, PhD

Postdoctoral Scholar and 2019 SPARED Seed Grant Awardee

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Erin Hisey, PhD

Postdoctoral Scholar

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Claudia Klengel, MD

Lab Manager

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Stephanie Maddox, PhD

Assistant Neuroscientist

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Emily Newman, PhD

Research Fellow

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Cameron Pernia, PhD

Postdoctoral Scholar

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