SPARED | Research

Administrative Core

The Administrative Core maintains the organizational structure necessary for enabling successful communication, integration, and cooperation among SPARED Center projects,…

Project One: Cell specific PACAP-CRF effects in Mice

The goal of Project 1 is to dissect the molecular events within specific neuron populations that underlie the stress response. Project 1 is designed to operate at a deep…

Project Two: PACAP-CRF effects on anxiety circuits in mice

The goal of Project 2 is to understand how PACAP and CRF interact within the basolateral amygdala (BLA) and the BNST to regulate anxiety-related behaviors. Two neuropeptides,…

Project Three: Roles of PACAP-CRF systems in sleep in mice

The goal of Project 3 is to develop a more comprehensive understanding of how PACAP and CRF systems sleep and circadian rhythm. Sleep is affected in many psychiatric illnesses.…

Project Four: Clinical studies of PACAP-CRF systems in human PTSD

The goal of Project 4 is to determine whether variation in CRF and PACAP system signaling tracks with hyperarousal intermediate phenotypes in women and men with PTSD. Although…

Project Five: PACAP-CRF in postmortem human PTSD

The goal of Project 5 is to elucidate relationships among PACAP and CRF signaling, circadian rhythm regulation, and sex differences in the pathophysiology of PTSD from postmortem…